# Unmasking the Veiled Intruder: A Complicated Case of Eosinophilic Fasciitis

**Authors:** Asif Uddin, Daniel Lozeau, Asha Patnaik

PMC · DOI: 10.7759/cureus.63912 · Cureus · 2024-07-05

## TL;DR

This paper presents a rare case of eosinophilic fasciitis, highlighting its unique skin and tissue features compared to similar diseases.

## Contribution

The paper contributes a detailed case study emphasizing the diagnostic importance of clinical and histological features in eosinophilic fasciitis.

## Key findings

- A patient with skin thickening was diagnosed with eosinophilic fasciitis via skin biopsy.
- EF is distinguished from systemic sclerosis by lack of organ involvement and presence of peripheral eosinophilia.
- The case highlights the importance of recognizing EF's unique clinical presentation and histology.

## Abstract

Eosinophilic fasciitis (EF) is a rare inflammatory disease characterized by skin and fascial thickening. Unlike systemic sclerosis, EF lacks internal organ involvement and specific autoantibodies, with peripheral eosinophilia as a hallmark feature. Patients may exhibit joint pain and contractures due to fibrosis. We present a case of a patient who presented with skin thickening involving her upper and lower extremities and was ultimately diagnosed with EF based on a skin biopsy. This case underscores the importance of recognizing the unique clinical and histological features of EF.

## Linked entities

- **Diseases:** Eosinophilic fasciitis (MONDO:0009175), systemic sclerosis (MONDO:0005100)

## Full-text entities

- **Diseases:** joint pain (MESH:D018771), peripheral eosinophilia (MESH:D004802), contractures (MESH:D003286), inflammatory disease (MESH:D007249), systemic sclerosis (MESH:D012595), fibrosis (MESH:D005355), EF (MESH:C562487)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11298238/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC11298238/full.md

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Source: https://tomesphere.com/paper/PMC11298238