# Efficacy and safety of batroxobin in patients with acute ischemic stroke: A multicenter retrospective analysis

## TL;DR

Batroxobin treatment reduced stroke recurrence and improved recovery in patients with acute ischemic stroke beyond the window for clot-dissolving therapy.

## Contribution

Demonstrates batroxobin's efficacy in reducing stroke recurrence and improving outcomes in patients outside thrombolytic therapy time window.

## Key findings

- Batroxobin reduced stroke recurrence by 56.7% compared to standard therapy.
- Treatment improved 90–120 day disability outcomes without increasing bleeding risks.
- Only 1.2% of batroxobin-treated patients experienced moderate-to-severe bleeding.

## Abstract

The objective of this study was to evaluate the effectiveness of batroxobin in improving functional outcomes and reducing stroke recurrence among patients with acute ischemic stroke beyond the therapeutic time window for thrombolytic therapy.

This multicenter, retrospective study enrolled 492 patients with acute moderate‐to‐severe ischemic stroke within 24 h. 238 patients were given standard (basic) therapy. On the basis of standard treatment, 254 patients received an initial intravenous infusion of batroxobin 10 U on day 1, followed by subsequent infusions of batroxobin 5 U on the 3rd and 5th days, respectively.

In the batroxobin group, 8.3% of patients experienced recurrence stroke, compared to 17.2% in the control group (HR, 0.433; 95% CI, 0.248 to 0.757; p = 0.003). Furthermore, intravenous batroxobin significantly improved the distribution of 90–120 day disability. Moderate‐to‐severe bleeding events were reported in three patients (1.2%) in the batroxobin group and one patient (0.4%) in the control group (p = 0.369).

Among patients with acute moderate‐to‐severe ischemic stroke beyond the time window for thrombolytic therapy, treatment with intravenous batroxobin had a lower risk of stroke recurrence and a better recovery of function outcome without increasing bleeding events. Prospective studies are needed to further confirm.

Intravenous batroxobin treatment was found to significantly reduce the risk of stroke recurrence and improve functional outcomes for patients with acute ischemic stroke beyond the thrombolytic therapy time window. Additionally, the treatment did not lead to an increase in moderate‐to‐severe bleeding events.