# A Rare Presentation of Glucose-6-Phosphate Dehydrogenase Deficiency

## TL;DR

A 12-year-old boy with acute liver failure and hemolysis was found to have G6PD deficiency worsened by a viral infection and NSAID use.

## Contribution

This case highlights a rare and complex presentation of G6PD deficiency triggered by a viral infection and NSAID intake.

## Key findings

- The patient's symptoms were initially misattributed to acetaminophen toxicity and hepatitis A.
- G6PD deficiency was confirmed as the underlying cause after ruling out other possibilities.
- The condition was exacerbated by a viral infection and NSAID use.

## Abstract

Approximately 400 million individuals globally experience glucose-6-phosphate dehydrogenase (G6PD) insufficiency, an enzymatic condition that may be hazardous. Because of mutations in the G6PD gene, which result in functional variants alongside a variety of biochemical and clinical symptoms, this condition is an X-linked hereditary genetic disorder. Our case is that of a 12-year-old male child who presented with acute liver failure and later on, exhibited signs of hemolysis as well. We had to rule out the possibilities of acetaminophen toxicity and hepatitis A before reaching the conclusion that an underlying G6PD deficiency was being exacerbated by viral infection and simultaneous ingestion of non-steroidal anti-inflammatory drugs (NSAIDs).