# Hyperhomocysteinemia in a Patient With Subdural Hematoma and Subarachnoid Hemorrhage Secondary to a Traumatic Brain Injury

## TL;DR

This paper reports a case where high homocysteine levels were linked to severe brain injuries and highlights its potential as a diagnostic tool.

## Contribution

The novelty lies in demonstrating hyperhomocysteinemia's role in traumatic brain injury prognosis through a clinical case.

## Key findings

- Elevated homocysteine levels were observed in a patient with traumatic brain injury.
- Post-operative homocysteine levels decreased, suggesting a potential link to recovery.
- Homocysteine may serve as a non-invasive biomarker for brain injury severity.

## Abstract

Traumatic brain injury (TBI) is a significant global health issue, contributing substantially to mortality and disability. Serum biomarkers, such as homocysteine (Hcy), play a critical role in the prognosis of brain injuries, with hyperhomocysteinemia (HHcy) potentially leading to neurological disorders. We present the case of a 64-year-old patient admitted to the emergency department following a road traffic accident (RTA). Magnetic resonance imaging (MRI) revealed parietal subdural hematoma (SDH), right frontal contusion, and left subarachnoid hemorrhage (SAH). The patient underwent a craniotomy to address SAH and SDH. Initial Hcy levels were markedly elevated compared to post-operative levels. Hcy represents a rapid, non-invasive, and cost-effective diagnostic tool for assessing brain injury severity and guiding medical intervention. Early detection of HHcy could potentially mitigate vascular and neurological complications, thereby improving patient outcomes.