# Tricyclic Antidepressant and Antipsychotic Toxicity: Clomipramine and Ziprasidone Overdose

## TL;DR

A case report describes a severe overdose involving tricyclic antidepressants and antipsychotics, highlighting the toxic effects and successful treatment.

## Contribution

The report emphasizes the rapid onset and amplification of toxicity from combined drug overdose.

## Key findings

- Overdose with clomipramine and ziprasidone caused severe neurological, pulmonary, and cardiac effects.
- Toxic effects peaked within six hours and were managed successfully with poison control guidance.
- Co-ingestion amplified clinical toxidromes, underscoring the risks of combined drug overdose.

## Abstract

This case report details an intentional overdose attempt utilizing tricyclic antidepressants (TCAs) and atypical antipsychotics with significant neurologic, pulmonary, and cardiac toxicity. In conjunction with the local poison control center, progression of the clinical toxidrome was anticipated, aggressively managed, and successfully treated. This case highlights the dangers of significant TCA toxicity, peak onset of toxicity within six hours, and the amplification of clinical toxidromes with co-ingestions.