# Case Report: Activated B-cell-diffuse large B-cell lymphoma

## TL;DR

This case report describes a rare oropharyngeal lymphoma diagnosed as activated B-cell-diffuse large B-cell lymphoma in a female patient.

## Contribution

The report highlights the clinical, histological, and immunohistochemical features of a rare lymphoma case to aid in early diagnosis.

## Key findings

- The patient presented with a palatal swelling and ulceroproliferative lesion.
- Diagnosis of activated B-cell-diffuse large B-cell lymphoma was confirmed via punch biopsy and immunohistochemistry.
- The case emphasizes the importance of correlating clinical and pathological findings for accurate diagnosis.

## Abstract

Lymphomas of the oral and oropharyngeal regions are rather uncommon, and diagnosis can be challenging and confusing due to the multiple histological subgroups. Lymphomas are the third most common type of tumor in the head and neck region and are brought on by the lymphoreticular system. The two forms of lymphoma are Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (NHL). Herein, we present a case report of oropharyngeal lymphoma. The female patient reported with a complaint of swelling over the palatal region for two to three months. An ulceroproliferative lesion was evident over the posterior palatal region. We diagnosed reactive lymphadenitis based on an incisional biopsy. To confirm the diagnosis and rule out other conditions, a punch biopsy followed by immunohistochemical studies were done. Features suggestive of activated B-cell-diffuse large B-cell lymphoma were confirmed. Among malignant lymphomas, diffuse large B-cell lymphoma is the most prevalent variety. Much progress has been made in recent years in understanding the molecular pathophysiology of this disease. In this case report, we aim to correlate the clinical presentation, histology features and immunohistochemical significance in order to promote early discovery, diagnosis, and treatment for a better prognosis of the patient.