# Recent advances of PIWI‐interacting RNA in cardiovascular diseases

## TL;DR

This paper reviews how piRNA, a type of noncoding RNA, may serve as a new biomarker or treatment target for cardiovascular diseases.

## Contribution

The paper highlights recent advances in understanding piRNA's role in cardiovascular diseases and its potential as a therapeutic target.

## Key findings

- piRNA influences apoptosis, inflammation, and angiogenesis through epigenetic modifications.
- piRNA has potential as a biomarker and therapeutic target for cardiovascular diseases.
- Knowledge gaps remain in piRNA nomenclature and PIWI-independent functions.

## Abstract

The relationship between noncoding RNAs (ncRNAs) and human diseases has been a hot topic of research, but the study of ncRNAs in cardiovascular diseases (CVDs) is still in its infancy. PIWI‐interacting RNA (piRNA), a small ncRNA that binds to the PIWI protein to maintain genome stability by silencing transposons, was widely studied in germ lines and stem cells. In recent years, piRNA has been shown to be involved in key events of multiple CVDs through various epigenetic modifications, revealing the potential value of piRNA as a new biomarker or therapeutic target.

This review explores origin, degradation, function, mechanism and important role of piRNA in CVDs, and the promising therapeutic targets of piRNA were summarized. This review provide a new strategy for the treatment of CVDs and lay a theoretical foundation for future research.

piRNA can be used as a potential therapeutic target and biomaker in CVDs.piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions.Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI‐independent function.

piRNA can be used as a potential therapeutic target and biomaker in CVDs.

piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions.

Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI‐independent function.

1. piRNA is a class of small noncoding RNA.2. piRNA plays a variety of biological functions in vivo.3. piRNA plays an important role in CVDs.

1. piRNA is a class of small noncoding RNA.

2. piRNA plays a variety of biological functions in vivo.

3. piRNA plays an important role in CVDs.