# Association between polymorphisms of DNA repair genes and intracranial aneurysms: A systematic review and meta‑analysis

## TL;DR

This study reviews how DNA repair gene variations may be linked to intracranial aneurysms, finding specific genetic markers that increase risk.

## Contribution

The study identifies specific SNPs (rs2287926 and rs251124) associated with intracranial aneurysm risk through a meta-analysis of genetic data.

## Key findings

- The rs2287926 G/G genotype and G allele are linked to increased intracranial aneurysm risk.
- The rs251124 T/T genotype and T allele also increase the risk of developing intracranial aneurysms.

## Abstract

Intracranial aneurysms (IAs) are present in ~2% of the general population, and genetic factors cannot be excluded for the risk of their development. The gene factors that result in the changes in the vascular extracellular matrix (ECM) may also be a key reason for IAs being hereditary. The VCAN gene [also known as chondroitin sulfate proteoglycan 2 (CSPG2)] plays various roles in maintaining ECM functions. The present systematic review and meta-analysis aimed to investigate all eligible articles involving IAs on the association with germ line SNPs of DNA repair genes (up to January, 2024). The total number of patients was 2,308 [987 cases (poor outcomes) and 1,321 controls (good outcomes)]. The results revealed that rs2287926 G/G genotype and G allele and rs251124 T/T genotype and minor allele T increased the risk of developing IAs. However, further studies are required to examine these gene polymorphisms as screening markers for IAs.