Association between glycemia and multi-vessel lesion in participants undergoing coronary angiography: a cross-sectional study

TL;DR

This study finds that higher blood sugar levels are linked to a greater risk of multi-vessel heart disease, especially in men, older adults, and smokers.

Contribution

The study identifies a significant association between glycemia and multi-vessel coronary lesions, with subgroup effects based on gender, age, and smoking.

Findings

Higher glycemia levels correlate with increased risk of multi-vessel coronary lesions (OR 1.04; p = 0.02).

Each unit increase in glycemia raises multi-vessel lesion risk by 4% in adjusted models.

The effect is stronger in men, older individuals, and smokers.

Abstract

This study aims to elucidate the association between glycemia and the occurrence of multi-vessel lesions in participants undergoing coronary angiography.

We analyzed 2,533 patients with coronary artery disease who underwent coronary angiography. Of these, 1,973 patients, identified by the endpoint of multi-vessel lesions, were examined using univariate and multivariate logistic regression analyses to determine the relationship between glycemia levels and multi-vessel lesion occurrence.

The analysis included 1,973 participants, among whom 474 patients were identified with coronary multi-vessel lesions. Univariate logistic regression analysis demonstrated a positive correlation between glycemia and the occurrence of coronary multi-vessel lesions (OR 1.04; 95% CI 1.01–1.08; p = 0.02). The adjusted model indicated that for each unit increase in glycemia, the risk of developing coronary multi-vessel lesions increased by 4%, showing a significant correlation (p < 0.05). Subgroup analyses revealed that the impact of glycemia on multi-vessel lesions in patients with PCI varied according to gender, age, and smoking status, with the effect being more pronounced in men, older patients, and smokers.

Our findings establish a significant association between glycemia and the incidence of multi-vessel lesions, particularly pronounced in male patients, individuals over 45, and smokers.

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