Relationship between polycystic ovary syndrome and high periostin level

TL;DR

This study found that women with polycystic ovary syndrome have higher levels of a protein called periostin, which may help assess the severity of the condition.

Contribution

The study demonstrates that periostin levels are significantly elevated in polycystic ovary syndrome patients, suggesting a potential biomarker for disease severity.

Findings

Periostin levels were significantly higher in polycystic ovary syndrome patients compared to controls (4.67±2.46 vs. 2.60±1.41 ng/mL).

The study suggests that periostin could serve as a potential marker for assessing disease severity in polycystic ovary syndrome.

Abstract

There is growing evidence suggesting a relationship between periostin levels, inflammation, and ovarian dysfunction. In this prospective case-control study, we aimed to investigate serum periostin levels and their relationship with metabolic parameters in patients with polycystic ovary syndrome.

We conducted a prospective case-control study involving 45 polycystic ovary syndrome patients and 45 control subjects, matched in a 1:1 ratio. Serum samples collected from both study and control groups were analyzed using enzyme-linked immunosorbent assay.

The demographic characteristics were similar between the polycystic ovary syndrome and control groups (p>0.05). Periostin levels were significantly higher in patients with polycystic ovary syndrome compared with the control group (4.67±2.46 vs. 2.60±1.41 ng/mL, respectively; p=0.000).

Our study revealed a significant elevation in periostin levels among polycystic ovary syndrome patients compared with controls. These findings suggest that periostin could serve as a potential marker for assessing disease severity in polycystic ovary syndrome patients.