# Multiple Episodes of Cardiac Arrest Induced by Treatment With Ibogaine: A Case Report

**Authors:** David Mestre, Alexandra Paula, Francisco P Gil, José Vaz

PMC · DOI: 10.7759/cureus.63487 · Cureus · 2024-06-29

## TL;DR

A patient experienced multiple cardiac arrests after taking a low dose of ibogaine, highlighting its dangerous heart-related risks.

## Contribution

This case report demonstrates the lethal cardiotoxic potential of ibogaine, even at low doses.

## Key findings

- A patient had multiple cardiac arrests after a 200mg ibogaine dose.
- The patient had no structural heart disease, indicating ibogaine's direct cardiotoxic effect.
- Low-dose ibogaine can cause life-threatening QT prolongation.

## Abstract

Opioid dependence is a common problem, and therapeutic alternatives are scarce and ineffective. Ibogaine, illegal in several countries, has been reported as a possible therapy in alternative clinics and it is also used as a recreational drug, despite its cardiotoxic potential, including QT prolongation.

We report a case of long QT leading to multiple episodes of cardiac arrest after a single dose of ibogaine (200mg, 2.6mg/Kg) in a patient without structural heart disease. This case highlights the fact that even low doses of ibogaine can be lethal and warns us about the consequences of its use.

## Linked entities

- **Chemicals:** ibogaine (PubChem CID 197060)
- **Diseases:** opioid dependence (MONDO:0005530)

## Full-text entities

- **Diseases:** QT prolongation (MESH:D008133), cardiotoxic (MESH:D066126), Cardiac Arrest (MESH:D006323), heart disease (MESH:D006331)
- **Chemicals:** Ibogaine (MESH:D007050)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11287021/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11287021/full.md

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Source: https://tomesphere.com/paper/PMC11287021