# Rare but There: Ceftriaxone-Induced Neutropenia in a Patient With a Brain Abscess

## TL;DR

A 70-year-old man developed neutropenia after prolonged ceftriaxone treatment for a brain abscess, highlighting the need for monitoring and timely intervention.

## Contribution

This case report highlights ceftriaxone-induced neutropenia as a rare but important complication in prolonged antibiotic therapy.

## Key findings

- Neutrophil counts dropped significantly after eight weeks of ceftriaxone treatment.
- Discontinuation of ceftriaxone and G-CSF administration restored neutrophil levels.
- The case underscores the importance of monitoring for neutropenia during prolonged ceftriaxone therapy.

## Abstract

This case report details the case of a 70-year-old man with Marfan syndrome and hypertension who developed neutropenia after an eight-week course of ceftriaxone, used to treat a brain abscess. Initially presenting with tonic-clonic seizures and headaches, his condition was managed with ceftriaxone and metronidazole. The subsequent drop in neutrophil counts from 7.54 × 10^9/L to 0.87 × 10^9/L leads to the discontinuation of ceftriaxone and the administration of granulocyte-colony stimulating factor (G-CSF), which effectively restored the neutrophil levels. This case highlights that clinicians should be aware of ceftriaxone-induced neutropenia as a potential complication, especially in patients undergoing prolonged therapy. Regular monitoring and timely management are essential for patient safety and favorable outcomes.