# Grand challenges in molecular cardiology **Authors:** Leon J. De Windt PMC · DOI: 10.3389/fmmed.2022.920039 · Frontiers in Molecular Medicine · 2022-11-18 ## Full-text entities - **Genes:** EDN1 (endothelin 1) [NCBI Gene 1906] {aka ARCND3, ET1, HDLCQ7, PPET1, QME}, AGT (angiotensinogen) [NCBI Gene 183] {aka ANHU, SERPINA8, hFLT1} - **Diseases:** Valve disease (MESH:D006349), organ dysfunction (MESH:D009102), diabetes (MESH:D003920), long QT syndrome (MESH:D008133), acute coronary syndromes (MESH:D054058), angina pectoris (MESH:D000787), ventricular tachyarrhythmias (MESH:D014693), Arrhythmias (MESH:D001145), hereditary cardiomyopathies (MESH:D009386), atherosclerosis (MESH:D050197), death (MESH:D003643), inflammatory (MESH:D007249), fibrosis (MESH:D005355), hypertension (MESH:D006973), stroke (MESH:D020521), conduction abnormalities (MESH:D054537), Cardiac disease (MESH:D006331), congenital heart disease (MESH:D006330), microvascular dysfunction (MESH:D017566), intermittent claudication (MESH:D007383), Cardiac remodeling (MESH:D020257), HF (MESH:D006333), MI (MESH:D009203), ischemic heart disease (MESH:D017202), congenital and acquired (MESH:D000163), stenosis (MESH:D003251), vascular malfunction (MESH:D057772), insulin resistance (MESH:D007333), chronic inflammatory diseases (MESH:D002908), restenosis (MESH:D023903), thrombosis (MESH:D013927), cardiac hypertrophy (MESH:D006332), ischemic (MESH:D002545), Cardiovascular diseases (MESH:D002318), dyslipidemia (MESH:D050171), vascular disorders (MESH:D002561), intimal hyperplasia (MESH:D006965), Vascular disease (MESH:D014652) - **Chemicals:** catecholamines (MESH:D002395), oxygen (MESH:D010100), calcium (MESH:D002118) - **Species:** Oryctolagus cuniculus (domestic rabbit, species) [taxon 9986], Mus musculus (house mouse, species) [taxon 10090], Sus scrofa (pig, species) [taxon 9823], Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11285535/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11285535/full.md ## References 15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11285535/full.md --- Source: https://tomesphere.com/paper/PMC11285535