# Effect of Antibiotic Therapy Before Arthrocentesis on Synovial Fluid Cell Count and Differential for Diagnosis of Native Joint Septic Arthritis

## TL;DR

This study investigates how antibiotic use before joint fluid testing affects diagnostic markers for joint infections.

## Contribution

The study reveals that antibiotic duration, but not prior exposure, impacts synovial fluid cell counts.

## Key findings

- Pre-arthrocentesis antibiotic exposure did not alter synovial fluid parameters.
- Longer antibiotic duration was linked to lower total nucleated cell counts in synovial fluid.

## Abstract

We examined the effect of preoperative antibiotic exposure and duration on synovial fluid samples from patients with native joint septic arthritis of the hip/knee. While exposure before diagnostic arthrocentesis did not affect fluid parameters, increased duration was associated with a decreased total nucleated cell count, underscoring the complex antibiotic effects on synovial fluid parameters.

Graphical AbstractThis graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/effect-of-antibiotic-therapy-before-arthrocentesis-on-synovial-fluid-cell-count-and-differential-for-diagnosis-of-native-joint-septic-arthritis-3c2a7a4f-75e8-487a-94fc-c2a432c7adf9

This graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/effect-of-antibiotic-therapy-before-arthrocentesis-on-synovial-fluid-cell-count-and-differential-for-diagnosis-of-native-joint-septic-arthritis-3c2a7a4f-75e8-487a-94fc-c2a432c7adf9