# Isocitrate Dehydrogenase (IDH)-Mutant High-Grade Glioma in the Cerebellum: A Case Report

## TL;DR

This case report describes a rare instance of IDH-mutant high-grade glioma in the cerebellum, highlighting its diagnostic features and molecular confirmation.

## Contribution

The novelty lies in presenting a rare cerebellar case of IDH-mutant high-grade glioma with detailed diagnostic and molecular analysis.

## Key findings

- IDH-mutant high-grade glioma was diagnosed in the cerebellum of an elderly patient.
- Histopathology and immunohistochemistry confirmed the glioma's IDH-mutant status.
- Molecular studies aided in the accurate classification of the tumor.

## Abstract

High-grade glial cancers typically arise in the cerebral hemisphere and rarely in the cerebellum. Our objective was to highlight the diagnostic features of isocitrate dehydrogenase (IDH)-mutant high-grade gliomas in the cerebellum. We present a case of an elderly patient admitted with giddiness who was diagnosed with IDH-mutant high-grade glioma in the cerebellum, presenting as multiple lesions. We evaluated an open biopsy specimen to arrive at a diagnosis and used molecular studies to confirm the diagnosis and further categorize the specimens. Histopathology and immunohistochemistry confirmed the diagnosis of IDH-mutant high-grade glioma in the cerebellum.