# Pneumocystis Pneumonia Presenting With Peripheral Predominant Consolidation and Traction Bronchiectasis

**Authors:** Nobuhiro Fujishima, Yoshihide Hioki, Atsushi Yokoyama, Kazufumi Hiramatsu, Kosaku Komiya

PMC · DOI: 10.7759/cureus.63257 · Cureus · 2024-06-26

## TL;DR

A rare case of Pneumocystis pneumonia presented with unusual lung imaging features, successfully treated with antibiotics.

## Contribution

Reports a novel case of PCP with peripheral consolidation and traction bronchiectasis, not previously documented.

## Key findings

- PCP presented with peripheral consolidation and traction bronchiectasis in lower lobes on HRCT.
- Diagnosis was confirmed via bronchoalveolar lavage and HIV testing.
- Symptoms resolved after treatment with trimethoprim-sulfamethoxazole.

## Abstract

Pneumocystis jirovecii pneumonia (PCP) typically presents as a predominant ground-glass opacity (GGO) in the upper lobes. We report a case of a patient with PCP that mimicked organizing pneumonia or nonspecific interstitial pneumonia, showing peripheral predominant consolidation with traction bronchiectasis and peribronchovascular thickening in the lower lobes on high-resolution computed tomography (HRCT). Pneumocystis jirovecii was detected in bronchoalveolar lavage (BAL), and no other pathogens were isolated. After confirmation of a high plasma human immunodeficiency virus (HIV)-RNA titer and a low CD4+ cell count, the patient was diagnosed with PCP associated with HIV infection. The peripheral predominant consolidation was successfully resolved after treatment with trimethoprim-sulfamethoxazole. To the best of our knowledge, no previous case of PCP presenting with peripheral predominant consolidation, traction bronchiectasis, or peribronchovascular thickening has been reported. Physicians should consider PCP as a differential diagnosis even in cases suspected as organizing pneumonia or nonspecific interstitial pneumonia on HRCT.

## Linked entities

- **Chemicals:** trimethoprim-sulfamethoxazole (PubChem CID 358641)
- **Diseases:** Pneumocystis pneumonia (MONDO:0019121), organizing pneumonia (MONDO:0015264), nonspecific interstitial pneumonia (MONDO:0019622), HIV infection (MONDO:0005109)
- **Species:** Pneumocystis jirovecii (taxon 42068)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** PCP (MESH:D011020), HIV infection (MESH:D015658), organizing pneumonia (MESH:D000092124), Traction Bronchiectasis (MESH:D001987), interstitial pneumonia (MESH:D017563)
- **Chemicals:** trimethoprim-sulfamethoxazole (MESH:D015662)
- **Species:** Pneumocystis jirovecii (species) [taxon 42068], Human immunodeficiency virus (species) [taxon 12721], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11282382/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC11282382/full.md

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Source: https://tomesphere.com/paper/PMC11282382