# Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS

## TL;DR

This study shows that knocking down the SDC-1 gene in mice changes metabolic pathways, potentially offering a new treatment for hemorrhagic shock.

## Contribution

The study integrates transcriptomics and metabolomics to reveal novel metabolic pathway changes in SDC-1 knockout mice under shock.

## Key findings

- SDC-1 knockout altered fat digestion, GnRH signaling, and fructose and mannose metabolism.
- Shock in SDC-1 knockout mice modulated longevity-related and vitamin metabolism pathways.
- Increased nicotinamide metabolism in SDC-1 knockout mice suggests potential therapeutic benefits for hemorrhagic shock.

## Abstract

This study aims to reveal the metabolic differences between SDC-1 knockout mice and wild-type mice and the metabolic differences caused by shock in SDC-1 knockout mice by integrating transcriptomics and metabolomics. A total of 1009 differential metabolites were differentially expressed based on untargeted metabolomics and high-resolution mass spectrometry detection techniques. According to Kyoto Encyclopedia of Genes and Genomes enrichment, SDC-1 knockout significantly altered fat digestion and absorption, GnRH signaling pathway, fructose and mannose metabolism, and some other amino-related metabolic pathways and significantly modulated positively regulated longevity regulatory pathways, longevity regulatory pathways-worm, nicotinamide and niacinamide metabolism, and vitamin digestion and absorption pathways after its shock. Our findings indicate that SDC-1 knockout may have potential therapeutic effects in hemorrhagic shock by increasing nicotinamide metabolism.

The online version contains supplementary material available at 10.1007/s12033-023-00809-9.