# Two-Dimensional Estrone-Imprinted System on a Self-Assembled Monolayer

## TL;DR

This study creates a sensor that can detect estrone with high selectivity by imprinting its structure onto a gold surface.

## Contribution

A novel estrone-imprinted system is developed with improved selectivity for estrone over its analogs.

## Key findings

- The estrone-imprinted system showed selectivity factors between 0.19 and 0.67 for estrone analogs.
- The system effectively differentiated estrone from similar compounds.
- Molecular size differences significantly influence selectivity.

## Abstract

In this study, a thin poly (methyl methacrylate) coating was formed on a self-assembled monolayer formed on a gold plate after chemically binding estrone. Subsequently, the estrone molecules were hydrolyzed and extracted using a solvent to form a molecular-imprinted system. The estrone-imprinted gold plate was then used as a working electrode to measure the estrone recognition ability through electrochemical methods. The recognition ability of this working electrode was evaluated for similar compounds. The selectivity factors for the seven estrone analogs were measured, and these values ranged from 0.19 to 0.67. According to the experimental results, the estrone-imprinted system showed good differentiation of estrone from other estrone analogs. Comparing these selectivity factors with those of a previous study on a cholesterol-imprinted system, the relative molecular size difference between the target molecule and similar molecules had a significant impact on the selectivity factor.