Highly Parallel Droplet Dispensing Approach to Provide Homogeneous and Controllable Droplet Arrays for Diagnostic Test Manufacturing
Omid Rajabnia, Andreas Ernst, Nils Lass, Lutz Riegger, Roland Zengerle
TL;DR
This paper introduces a new method for precisely dispensing droplets in parallel, enabling uniform coatings for diagnostic tests and biosensors.
Contribution
The novel approach enables tunable droplet dispensing with precise control over volume and velocity for microscale applications.
Findings
Achieved tunable droplet volumes from 200 to 800 pL and velocities from 0.5 to 2.5 m/s.
Demonstrated uniform coatings suitable for lateral flow tests, ELISA plates, and biosensors.
Established general design rules for nozzle chip configurations with varying diameters and pitches.
Abstract
We introduce a novel approach for highly parallel droplet dispensing with precise control over the droplet parameters such as droplet volume, droplet velocity, etc. This approach facilitates the fabrication of homogeneous and precise thin layers with uniform coverage on defined small areas (e.g., a specific area of 1 × 1.4 mm2 in microfluidic channels or microwells). The presented approach ensures layer uniformity and high precision in X/Y extent and edge resolution, making it well suited for achieving precise and controlled coating for a variety of applications such as homogeneous coatings for lateral flow tests, ELISA plates, and biosensors for continuous glucose monitoring (CGM) devices. Our approach is based on direct liquid displacement employing a piston that is in direct contact with the liquid and an array of nozzles. Considering a variety of nozzle chip designs (i.e., varying…
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Taxonomy
TopicsInnovative Microfluidic and Catalytic Techniques Innovation · Nanomaterials and Printing Technologies · Microfluidic and Capillary Electrophoresis Applications