A Multiomics, Molecular Atlas of Breast Cancer Survivors
Brent A. Bauer, Caleb M. Schmidt, Kathryn J. Ruddy, Janet E. Olson, Cem Meydan, Julian C. Schmidt, Sheena Y. Smith, Fergus J. Couch, John C. Earls, Nathan D. Price, Joel T. Dudley, Christopher E. Mason, Bodi Zhang, Stephen M. Phipps, Michael A. Schmidt
TL;DR
This study uses multiomics to compare breast cancer survivors with healthy controls, revealing molecular differences that could inform new treatment strategies.
Contribution
The study provides a comprehensive molecular atlas of breast cancer survivors using multiomics data, highlighting novel metabolic and proteomic differences.
Findings
Breast cancer survivors had significantly higher polygenic risk scores compared to controls.
Carnitine, hexanoyl carnitine, and the Omega-3 Index showed significant differences between groups.
Proteomic and metagenomic analyses revealed pathway differences warranting further investigation.
Abstract
Breast cancer imposes a significant burden globally. While the survival rate is steadily improving, much remains to be elucidated. This observational, single time point, multiomic study utilizing genomics, proteomics, targeted and untargeted metabolomics, and metagenomics in a breast cancer survivor (BCS) and age-matched healthy control cohort (N = 100) provides deep molecular phenotyping of breast cancer survivors. In this study, the BCS cohort had significantly higher polygenic risk scores for breast cancer than the control group. Carnitine and hexanoyl carnitine were significantly different. Several bile acid and fatty acid metabolites were significantly dissimilar, most notably the Omega-3 Index (O3I) (significantly lower in BCS). Proteomic and metagenomic analyses identified group and pathway differences, which warrant further investigation. The database built from this study…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsMetabolomics and Mass Spectrometry Studies · Cancer, Lipids, and Metabolism · Cancer, Hypoxia, and Metabolism