Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Altynay Zh. Shaibek, Manshuk S. Nurmaganbetova, Aigerym R. Zhasymbekova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Irina A. Kolesnik, Evgenij A. Dikusar, Tatiana I. Terpinskaya, Vladimir A. Kulchitsky, Vladimir I. Potkin
TL;DR
This study creates new alkaloid-based compounds and tests their combined effect with common anticancer drugs on rat glioma cells.
Contribution
The synthesis of novel isoxazolylurea derivatives and their synergistic antitumor activity with multiple drugs on C6 glioma cells is presented.
Findings
Alkaloid-based isoxazolylureas were synthesized with high yield.
The compounds showed antitumor activity when combined with various anticancer drugs.
Quantum chemical and docking studies provided insights into the compounds' interactions.
Abstract
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.
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Taxonomy
TopicsSynthesis and Biological Evaluation · Chemical Reaction Mechanisms · Fluorine in Organic Chemistry