# Computational Fluid–Structure Interaction in Microfluidics

**Authors:** Hafiz Muhammad Musharaf, Uditha Roshan, Amith Mudugamuwa, Quang Thang Trinh, Jun Zhang, Nam-Trung Nguyen

PMC · DOI: 10.3390/mi15070897 · Micromachines · 2024-07-09

## TL;DR

This paper reviews how computational methods for fluid-structure interaction are advancing microfluidic devices and biomedical applications.

## Contribution

The paper provides a comprehensive review of computational FSI methods in micro elastofluidics and outlines future research directions.

## Key findings

- Computational FSI methods are crucial for designing microdevices like microvalves and micropumps.
- These methods enable precise control of fluidic and structural dynamics in biomedical applications.
- Current challenges include developing tools for complex, time-dependent microfluidic models.

## Abstract

Micro elastofluidics is a transformative branch of microfluidics, leveraging the fluid–structure interaction (FSI) at the microscale to enhance the functionality and efficiency of various microdevices. This review paper elucidates the critical role of advanced computational FSI methods in the field of micro elastofluidics. By focusing on the interplay between fluid mechanics and structural responses, these computational methods facilitate the intricate design and optimisation of microdevices such as microvalves, micropumps, and micromixers, which rely on the precise control of fluidic and structural dynamics. In addition, these computational tools extend to the development of biomedical devices, enabling precise particle manipulation and enhancing therapeutic outcomes in cardiovascular applications. Furthermore, this paper addresses the current challenges in computational FSI and highlights the necessity for further development of tools to tackle complex, time-dependent models under microfluidic environments and varying conditions. Our review highlights the expanding potential of FSI in micro elastofluidics, offering a roadmap for future research and development in this promising area.

## Full-text entities

- **Diseases:** Thoracic Aortic Aneurysm (MESH:D017545), hemodynamic abnormalities (MESH:D000014), cardiovascular (MESH:D002318), Arterial diseases (MESH:D002539), ATAA (MESH:D000094625), aneurysm (MESH:D000783), FSI (MESH:D020914), malaria (MESH:D008288), strokes (MESH:D020521), heart attacks (MESH:D009203), tumour (MESH:D009369), heart diseases (MESH:D006331), injury to people or property (MESH:C000719191), valve dysfunction (MESH:D006349), LBMs (MESH:C537881), IBM (MESH:D007102), atherogenesis (MESH:D050197)
- **Chemicals:** cellulose (MESH:D002482), PDMS (MESH:C013830), polypropylene (MESH:D011126), FSI (-), maleic anhydride (MESH:D008299), polymer (MESH:D011108), PMMA (MESH:D019904), silicon (MESH:D012825)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11278627/full.md

## References

268 references — full list in the complete paper: https://tomesphere.com/paper/PMC11278627/full.md

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Source: https://tomesphere.com/paper/PMC11278627