# Pediatric Diaphyseal Forearm Fracture Management with Biodegradable Poly-L-Lactide-Co-Glycolide (PLGA) Intramedullary Implants: A Longitudinal Study

**Authors:** Aba Lőrincz, Ágnes Mária Lengyel, András Kedves, Hermann Nudelman, Gergő Józsa

PMC · DOI: 10.3390/jcm13144036 · Journal of Clinical Medicine · 2024-07-10

## TL;DR

This study shows that biodegradable implants effectively treat pediatric forearm fractures, offering good healing and minimal scarring without the need for removal.

## Contribution

The study provides mid-term evidence supporting the use of PLGA implants as a viable alternative to traditional metal implants in pediatric patients.

## Key findings

- All patients achieved effective fracture stabilization and bone healing with PLGA implants.
- Functional range of motion was largely preserved, with minimal scarring and high patient satisfaction.
- PLGA implants eliminated the need for secondary removal surgeries in pediatric patients.

## Abstract

Background: Pediatric forearm fractures represent a substantial proportion of childhood injuries, requiring effective and minimally invasive treatments. Our study investigated the mid-term outcomes of biodegradable poly-L-lactide-co-glycolide (PLGA) intramedullary implants in managing diaphyseal forearm fractures in children. Methods: A follow-up cohort study was conducted with 38 patients treated with PLGA implants. Control examinations were performed one year post-operation, assessing bone healing through radiographic evaluations and functional outcomes using injured and uninjured limb range of motion (ROM) comparisons. Scarring was evaluated employing the Vancouver Scar Scale (VSS), and satisfaction via a questionnaire. Results: Children were predominantly female (76.4%), with a mean age of 9.71 (SD: 2.69) years. Effective fracture stabilization and bone healing were found in all patients, with a minor reduction (mean difference of −1.5°, p = 0.282) in elbow flexion on the operated side (139.3°) compared to the intact (140.8°). Elbow extension presented negligible average changes (0.2°, p = 0.098). Forearm movements were slightly reduced on the operated side (mean pronation: 80.8° vs. 83.7°, p = 0.166; average supination: 83.5° vs. 85.7°, p = 0.141). Wrist palmar flexion and dorsiflexion showed no significant differences. VSS ratings indicated minimal scarring (mean guardian and doctor scores were 1.13 and 0.55, respectively, p = 0.020), and all patients reported satisfaction with the treatment outcomes. Conclusions: Biodegradable implants are effective for pediatric forearm fractures, providing stable bone healing while preserving functional ROM with minimal scarring and high patient satisfaction. PLGA proved to be a viable alternative to traditional metal implants, eliminating secondary removal surgeries.

## Linked entities

- **Chemicals:** PLGA (PubChem CID 36797)

## Full-text entities

- **Diseases:** fracture (MESH:D050723), injuries (MESH:D014947), Diaphyseal Forearm Fracture (MESH:D000092503)
- **Chemicals:** PLGA (MESH:D000077182), metal (MESH:D008670)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11277197/full.md

## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC11277197/full.md

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Source: https://tomesphere.com/paper/PMC11277197