# About two unusual cases of pancreatic primary squamous cell carcinoma

## TL;DR

This paper reports two rare cases of pancreatic primary squamous cell carcinoma and discusses diagnostic and treatment challenges.

## Contribution

The novelty lies in presenting two distinct PPSCC cases and emphasizing the role of immunohistochemistry in diagnosis.

## Key findings

- PPSCC is rare and requires histology and IHC to exclude metastasis.
- Poorly differentiated PPSCC relies heavily on immunohistochemistry for diagnosis.
- There is no consensus on treatment, and prognosis remains poor.

## Abstract

Pancreatic primary squamous cell carcinoma (PPSCC) is very uncommon. The major diagnostic method is histology, and it requires the exclusion of a metastasis from a different primary location (lung, esophagus…). Herein, we describe two cases of a PPSCC (one in the head and the other one in the tail and the body of the pancreas) with a brief review of literature. When it comes to the poorly differentiated PPSCC, immunohistochemistry (IHC) is crucial. Regretfully, there is currently no unanimity on treatment, and the outcome is dismal.