# Unexpected Cataract Formation Following Valproate Treatment: A Case Report

**Authors:** Nayan Sinha, Pradeep S Patil, Aditi Ananta, Sneha B Suresh, Navaneetha Unni

PMC · DOI: 10.7759/cureus.63093 · Cureus · 2024-06-25

## TL;DR

This case report highlights a rare side effect of valproate medication: unexpected cataract formation in a patient.

## Contribution

The report adds to the limited evidence linking valproate treatment with cataract development.

## Key findings

- Cataract formation was observed in a patient receiving valproate treatment.
- The occurrence of cataracts as a side effect of valproate is rare and underreported.
- Regular eye exams are recommended for patients on valproate to detect visual issues early.

## Abstract

Valproic acid (VPA), or sodium valproate, is a frequently prescribed medication for many psychiatric conditions, notably for the management of bipolar affective disorder. While its common side effects are well known and thoroughly documented in medical literature, the occurrence of cataracts as a side effect is exceedingly rare. There is evidence of cataract formation with long-term use of VPA in a few studies. Recognizing this potential adverse effect is crucial. It is important to recommend that patients undergo regular eye examinations if they experience any visual disturbances or as a preventative measure to ensure effective management. This case report examines the unusual occurrence of cataract development associated with valproate use.

## Linked entities

- **Chemicals:** valproic acid (PubChem CID 3121), sodium valproate (PubChem CID 16760703)

## Full-text entities

- **Diseases:** Cataract Formation (MESH:D002386), visual disturbances (MESH:D014786), psychiatric (MESH:D001523), bipolar affective disorder (MESH:C564108)
- **Chemicals:** VPA (MESH:D014635)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11272151/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11272151/full.md

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Source: https://tomesphere.com/paper/PMC11272151