# Chronic Dermatographic Urticaria Secondary to Systemic Lupus Erythematosus

## TL;DR

A 26-year-old woman with SLE showed chronic dermatographic urticaria that improved with hydroxyzine, highlighting a rare skin manifestation of SLE.

## Contribution

This case report adds evidence to the under-recognized link between SLE and chronic dermatographic urticaria.

## Key findings

- Chronic dermatographic urticaria was observed in a patient with SLE.
- Hydroxyzine treatment led to significant improvement in symptoms without adverse effects.
- The case emphasizes the need for comprehensive management of rare SLE-related skin conditions.

## Abstract

Systemic lupus erythematosus (SLE) poses significant challenges in diagnosis and management due to its diverse clinical manifestations, including various skin abnormalities. Chronic dermatographic urticaria, although less recognized, has been suggested to have an association with SLE; however, evidence supporting this connection remains limited. We present a case of chronic dermatographic urticaria secondary to SLE in a 26-year-old female. Despite ineffective conventional treatments, the initiation of hydroxyzine resulted in notable symptom improvement without adverse effects. This case underlines the importance of recognizing and addressing less common dermatological manifestations in SLE, emphasizing the need for a comprehensive approach to optimize patient outcomes. It highlights the potential utility of hydroxyzine in managing the refractory symptoms of chronic dermatographic urticaria in SLE patients. This report contributes to the expanding evidence regarding the complex interplay between SLE and dermatographic urticaria, necessitating further research to understand underlying mechanisms and establish optimal treatment strategies. Enhanced awareness and understanding of such associations are crucial for facilitating early diagnosis and tailored management approaches in patients with SLE, ultimately improving their quality of life and clinical outcomes.