# Angiosarcoma of the Maxillary Sinus: A Case Report

## TL;DR

This case report describes a rare angiosarcoma in the maxillary sinus of a 56-year-old woman, diagnosed through imaging and confirmed via histopathology.

## Contribution

The novelty lies in presenting a rare case of nasal angiosarcoma with detailed clinical and diagnostic observations.

## Key findings

- A 56-year-old female presented with nasal obstruction and facial swelling, diagnosed with angiosarcoma of the maxillary sinus.
- Histopathological and immunohistological analysis confirmed the diagnosis of malignant spindle cell tumor.
- The patient opted for radiation therapy instead of surgical excision.

## Abstract

Angiosarcoma can be defined as a malignant neoplasm arising from the lining of the blood and lymphatic vessels, including the endothelial cells. It can occur in any body part, such as blood vessels, skin, liver, and breast. Its incidence varies based on the site. There are different underlying etiologies associated with the incidence of angiosarcoma. Clinical presentation depends on the site of origin. Angiosarcoma of the sinus or nasal openings can be observed as a tissue mass, lesions, obstructed nasal cavity, facial swelling, proptosis, anosmia, nasal discharge, and epistaxis. These are rare malignancies with very low incidence. Though it has been reported in all age groups, it is more common in adults in their sixth decade and more. Nasal angiosarcoma can be a diagnostic challenge due to its rarity. This is a case of a 56-year-old female with a major complaint of nasal obstruction and face swelling for two months. Physical examination revealed a pinkish polypoidal mass. A contrast-enhanced computed tomography scan showed a heterogeneously arterial enhancing soft-tissue lesion in the left maxillary sinus with significant erosive changes. Histopathological analysis revealed a malignant spindle cell tumor, which was confirmed by a CD34 immunohistology stain. The patient was advised surgical excision for further management, which was denied. The patient is undergoing radiation therapy and is on third cycle as per the last follow-up.