# An Unusual Case of Neurofascin 186 Neuropathy

**Authors:** Khushboo S Hatekar, Shalesh Rohatgi, Satish P Nirhale, Prajwal M Rao, Pravin U Naphade

PMC · DOI: 10.7759/cureus.63049 · 2024-06-24

## TL;DR

This paper presents a rare case of autoimmune neuropathy caused by the immune system attacking the neurofascin 186 protein in the nervous system.

## Contribution

The paper reports a unique clinical case of NF 186-positive autoimmune neuropathy and its treatment approach.

## Key findings

- NF 186 is a key protein involved in peripheral nerve function and its autoimmune attack leads to neuropathy.
- The case highlights specific clinical features and treatment strategies for NF 186-positive neuropathy.
- Autoimmune mechanisms targeting neurofascin 186 can cause inflammation and nerve damage.

## Abstract

Among the diverse array of neuropathies, autoimmune neuropathy stands out as a distinctive subset, where the body's immune system mistakenly attacks its nerve tissues, triggering inflammation and nerve damage. NF 186, also known as neurofascin 186, is a cell adhesion molecule crucial for the integrity and functioning of the peripheral nervous system. This case report highlights the clinical presentation specific to NF 186-positive autoimmune neuropathy and also the treatment modalities.

## Linked entities

- **Diseases:** autoimmune neuropathy (MONDO:0000774), neuropathy (MONDO:0005244)

## Full-text entities

- **Diseases:** inflammation (MESH:D007249), Neuropathy (MESH:D009422), autoimmune neuropathy (MESH:D020274), nerve damage (MESH:D000080902)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11268536/full.md

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Source: https://tomesphere.com/paper/PMC11268536