# Hyperhidrosis and Neurofibromatosis Type 1: A Case Report

## TL;DR

A 20-year-old man with hyperhidrosis and neurofibromatosis type 1 was diagnosed and treated in Saudi Arabia, highlighting the importance of comprehensive evaluation.

## Contribution

This case report documents a rare co-occurrence of hyperhidrosis and NF1 in Saudi Arabia.

## Key findings

- The patient exhibited hyperhidrosis and NF1 symptoms including café-au-lait macules and dural ectasia.
- Treatment with 20% aluminum chloride effectively managed the hyperhidrosis.
- Comprehensive evaluation confirmed the diagnosis and highlighted the need for further understanding of the disorder's mechanisms.

## Abstract

In this report, we present the case of a 20-year-old male with childhood-onset hyperhidrosis affecting his fingers and palm flexor surfaces. Dermatological examination revealed café-au-lait macules, palm and sole involvement, and axillary freckling. A starch-iodine test confirmed localized sweating. Neuroimaging identified neurofibromatosis type 1 (NF1) with subcutaneous nodules and dural ectasia in the thoracic spine. The patient was diagnosed with hyperhidrosis and NF1 based on diagnostic criteria, and he responded well to 20% aluminum chloride for treatment of hyperhidrosis. This case represents a unique occurrence of hyperhidrosis with NF1 in Saudi Arabia. Comprehensive evaluation, including systemic assessment, radiology, and starch-iodine testing, aids in diagnosis and understanding of the underlying mechanisms of this disorder, which remains unexplained.