# Neonatal Graves Disease Masquerading as Hemochromatosis

**Authors:** Liesbeth Maggiotto, Steven D Mittelman, Roja Fallah

PMC · DOI: 10.1210/jcemcr/luae132 · JCEM Case Reports · 2024-07-24

## TL;DR

A newborn with liver failure and high ferritin was found to have Graves disease, not hemochromatosis, showing the importance of considering thyroid issues in such cases.

## Contribution

Highlights a rare case where neonatal Graves disease was misdiagnosed as hemochromatosis.

## Key findings

- Neonatal Graves disease can present with liver failure and high ferritin levels.
- Treating hyperthyroidism resolved the liver failure and elevated ferritin.
- Graves disease should be considered in newborns with unexplained liver failure.

## Abstract

Thyroid autoimmunity is extremely common in the adult population and can affect pregnancy outcomes. Signs in the newborn can range from absent to severe, making the diagnosis easy to miss. We present an interesting case of neonatal Graves disease associated with intrauterine growth restriction, premature delivery, and liver failure with severely high ferritin, thought to be secondary to hemochromatosis. Treatment of the underlying hyperthyroidism caused a rapid resolution of the elevated ferritin and liver failure. This report highlights the importance of considering Graves disease in newborns with liver failure of unknown etiology.

## Linked entities

- **Diseases:** Graves disease (MONDO:0005364), hemochromatosis (MONDO:0006507), liver failure (MONDO:0100192)

## Full-text entities

- **Diseases:** hyperthyroidism (MESH:D006980), intrauterine growth restriction (MESH:D005317), Graves Disease (MESH:D006111), premature delivery (MESH:C536271), Thyroid autoimmunity (MESH:D013967), Hemochromatosis (MESH:D006432), liver failure (MESH:D017093)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11267223/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC11267223/full.md

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Source: https://tomesphere.com/paper/PMC11267223