# Presentation of Adult-onset Asthma and Periocular Xanthogranuloma with Intermediate Uveitis and Hodgkin's Lymphoma: A Case Report

## TL;DR

A 51-year-old man with a history of Hodgkin's lymphoma developed adult-onset asthma and periocular xanthogranuloma along with intermediate uveitis, suggesting a possible immunological link.

## Contribution

This case report highlights a rare association between adult-onset asthma, periocular xanthogranuloma, intermediate uveitis, and a history of Hodgkin's lymphoma.

## Key findings

- The patient presented with adult-onset asthma and periocular xanthogranuloma 10 years after Hodgkin's lymphoma diagnosis.
- Histopathologic examination confirmed the diagnosis of AAPOX.
- The case suggests immunological dysfunction may contribute to xanthogranulomatous disease.

## Abstract

To report a case of adult-onset asthma and periocular xanthogranuloma (AAPOX) in a patient with intermediate uveitis and a history of Hodgkin's lymphoma (HL).

A 51-year-old man with a past medical history of HL presented with blurred vision, asthma, and bilateral yellowish eyelid lesions. The eyelid lesions and asthma appeared 10 years after being diagnosed with HL. Physical examination was significant for multiple subcutaneous and firm eyelid masses in addition to the presence of pre-auricular and submandibular lymphadenopathies. Ophthalmic examination revealed bilateral intermediate uveitis and mild macular edema. Further systemic evaluations, including laboratory testing and imaging, were normal. Excisional biopsy of the eyelid lesions was performed and the histopathologic examination was consistent with the diagnosis of AAPOX.

The presence of AAPOX in a patient with intermediate uveitis and history of HL suggests that immunological dysfunction may play a role in the pathogenesis of adult orbital xanthogranulomatous disease.