# Longitudinal CT, MRI, and 18F-FDG PET/CT Imaging Findings of Peliosis Hepatis: A Case Report

## TL;DR

A 73-year-old woman with a history of cancer and multiple myeloma was found to have a rare liver condition called peliosis hepatis, which was confirmed through imaging and biopsy, and showed improvement after stopping a medication.

## Contribution

This case report provides a detailed longitudinal imaging analysis of peliosis hepatis and its regression following discontinuation of a suspected causative drug.

## Key findings

- Peliosis hepatis was diagnosed using CT, MRI, and 18F-FDG PET/CT imaging before being confirmed by biopsy.
- Discontinuation of raloxifene hydrochloride led to regression of PH lesions five months later.
- PH imaging findings can mimic malignancies, highlighting the importance of accurate diagnosis.

## Abstract

Peliosis hepatis (PH) is a rare benign vascular condition characterized by sinusoidal dilatation and the presence of blood-filled spaces within the liver. PH is often clinically asymptomatic and is discovered incidentally. It presents a clinical challenge as its imaging findings frequently mimic other pathologies, including primary or secondary malignancies and abscesses. In this article, we present a case of a 73-year-old woman with a history of recurrent tongue cancer treated by surgery and chemoradiotherapy, and concurrent multiple myeloma, in whom PH was incidentally discovered. Based on computed tomography, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging findings prior to biopsy, PH was diagnosed, and pathologically confirmed. Follow-up computed tomography five months after the discontinuation of raloxifene hydrochloride, a selective estrogen receptor modulator and a suspected drug causing PH, the regression of PH lesions was observed.