# Analysis of rescue strategies for acute thrombosis during STA-MCA bypass surgery and the literature review

## TL;DR

This study evaluates how well tirofiban works to treat sudden blood clots during a specific brain surgery, finding it effective without major complications.

## Contribution

The study introduces and validates intra-arterial tirofiban infusion as a novel rescue strategy for acute thrombosis during STA-MCA bypass surgery.

## Key findings

- All eight patients with acute thrombosis during surgery had successful recanalization using various tirofiban-based methods.
- Intra-arterial tirofiban infusion via microcatheter was identified as a simple and effective treatment option.
- No major ischemic or hemorrhagic complications occurred in patients treated with tirofiban.

## Abstract

STA-MCA bypass surgery is mainly used for Moyamoya disease, giant intracranial aneurysms, and resection of intracranial tumors requiring sacrifice of blood vessels. The intraoperative patency of the reconstructive vessels is critical to the efficacy of the procedure. This study aimed to evaluate the efficacy of intra-arterially infused tirofiban for the treatment of acute thrombosis during STA-MCA bypass surgery and countermeasures for acute thrombosis.

This study involved 209 patients (272 hemispheres) who underwent STA-MCA surgery between November 2020 and December 2023. Intraoperative acute thrombosis occurred in eight patients (3.83%,8 hemispheres). We retrospectively reviewed the clinical and imaging data, surgical procedure, and follow-up outcomes of eight patients. We implemented the different thrombolytic methods to evaluate the optimal thrombosis management during the bypass surgery. After three months, we assessed neurological functions using the modified Rankin Scale (mRS) and conducted a literature review using PubMed.

Eight patients (four male patients and four female patients) developed acute thrombosis during the bypass surgery. Of the eight patients, two underwent re-anastomosis after thrombus removal, three received local injections of tirofiban into the anastomosis or the branches of the superficial temporal artery, and three underwent superselective intra-arterial tirofiban infusion using a microcatheter. Thrombosis were resolved, and arteries were recanalized in all patients. The mRS score was 0 in all patients. No major ischemic or hemorrhagic complications occurred.

Our treatment methods were efficacious in the management of acute thrombosis. Intra-arterial tirofiban administration seems to be a simple and effective treatment option for acute thrombosis during STA-MCA bypass surgery.