# Iodine-125 brachytherapy in inoperable duodenal papilla carcinoma: a case report series

## TL;DR

This paper reports on using iodine-125 brachytherapy to treat two elderly patients with inoperable duodenal papilla cancer, showing tumor reduction and improved survival.

## Contribution

This is the first reported use of 125I seed implantation to effectively control inoperable duodenal papilla carcinoma.

## Key findings

- Tumor reduction was observed within two months after 125I seed implantation in two patients.
- Both patients showed radiological tumor response and survived over six months post-treatment.
- 125I seed implantation shows potential as a treatment for inoperable localized DPC.

## Abstract

Duodenal papilla carcinoma (DPC) is a rare malignancy often diagnosed at an advanced stage. When surgery is not feasible in localized disease due to advanced age or comorbidities, there remains no consensus on optimal management for these patients.

This case series details the therapeutic outcomes of 125I seed implantation in two elderly patients with DPC. A notable tumor reduction was achieved within two months after implantation. Furthermore, both patients demonstrated radiological tumor response and survived for over six months following the initial 125I seed treatment, marking the first reported instance of 125I seed implantation to effectively control DPC.

The anti-tumor activity of 125I seed implantation in the reported two cases of DPC underscores its potential as a viable treatment option for inoperable localized DPC.