# Dengue rhabdomyolysis successfully treated with hemoperfusion using CytoSorb® in combination with continuous renal replacement therapy: a case report

## TL;DR

A young man with dengue fever developed severe rhabdomyolysis and kidney failure, which was successfully treated with a combination of CytoSorb® and continuous kidney therapy.

## Contribution

This case report demonstrates the potential benefit of adding CytoSorb® to standard therapy for dengue-induced rhabdomyolysis and acute kidney injury.

## Key findings

- The patient's creatinine phosphokinase and myoglobin levels significantly decreased after adding CytoSorb® to his treatment.
- Complete renal recovery was observed over five weeks following the combined therapy.
- Standard treatments like hemodialysis and continuous hemodiafiltration alone were ineffective in controlling the patient's condition.

## Abstract

Dengue fever is a mosquito-borne viral infection with a broad spectrum of clinical manifestations. Expanded dengue syndrome includes unusual manifestations that do not fall into the categories of dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Rhabdomyolysis causing acute renal failure in dengue is one such unusual manifestation, the pathophysiology of which is incompletely understood.

We describe a 21-year-old Sri Lankan man with dengue fever who developed severe rhabdomyolysis and acute kidney injury with extremely high creatinine phosphokinase levels (> 2 million U/L). Management of this patient was challenging as his creatinine phosphokinase kept rising with persistent anuria despite hydration, intermittent hemodialysis, and, later, continuous venovenous hemodiafiltration. Further therapeutic options were explored, and CytoSorb® adsorber was added as an adjunct to continuous venovenous hemodiafiltration, following which we observed a marked reduction in his creatinine phosphokinase and myoglobin levels over the next 12 hours and complete renal recovery over the next 5 weeks.

We report a rare case of significant rhabdomyolysis secondary to dengue infection leading to acute kidney injury. Continuous venovenous hemodiafiltration performed with the hemofilter Pecopen 140 was ineffective, and the addition of CytoSorb® adsorber as an adjunct therapy to continuous venovenous hemodiafiltration may have a potential benefit in removing high-molecular-weight proteins such as myoglobin.