# A Rare Case of Life-Threatening Hemorrhage

## TL;DR

This paper presents a rare case of life-threatening bleeding caused by acquired hemophilia A in a patient with liver disease.

## Contribution

The novelty lies in diagnosing and managing acquired hemophilia A in a patient with primary biliary cholangitis.

## Key findings

- Acquired hemophilia A was identified as the cause of life-threatening bleeding in a patient with primary biliary cholangitis.
- Diagnosis and treatment of acquired hemophilia A provided critical management options not available otherwise.

## Abstract

Acquired hemophilia A is a rare but severe autoimmune bleeding disorder that results from autoantibodies against clotting factor VIII (FVIII). Distinguishing acquired hemophilia from other more common causes of bleeding, such as chronic liver disease, disseminated intravascular coagulation, or sepsis-induced coagulopathies, is crucial in guiding the management of life-threatening hemorrhage. This study describes a patient with primary biliary cholangitis who was found to have acquired hemophilia A, a unique cause of life-threatening bleeding that was especially challenging to diagnose and manage with her underlying liver disease. Identifying acquired hemophilia A allowed an avenue of treatment options that would not have otherwise been available.