# The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review

## TL;DR

This paper reviews how the p130Cas/BCAR1 protein contributes to cardiovascular diseases through various biological mechanisms.

## Contribution

The paper provides a comprehensive review of p130Cas/BCAR1's role in cardiovascular diseases, highlighting potential therapeutic implications.

## Key findings

- p130Cas/BCAR1 influences cardiac development defects and remodeling.
- It contributes to pulmonary artery hypertension and atherosclerosis via ROS and RTK signaling.
- The protein interacts with FAK and Ang II, affecting stress fiber formation and growth signaling.

## Abstract

Breast cancer anti-estrogen resistance-1 (p130Cas/BCAR1) is an adaptor protein of the cas(Cas) family. This protein regulates multiple complex pathways in different organs including bones, pancreas, and immune and cardiovascular systems. Although previous research well demonstrated the role of p130Cas/BCAR1 in different diseases especially cancers, a precise review study on the various effects of p130Cas/BCAR1 on cardiovascular diseases is missing. In this study, we reviewed mechanisms of action for p130Cas/BCAR1 impact, on cardiac embryonic development defects, hypertrophy and remodeling, pulmonary artery hypertension (PAH), and atherosclerosis. Also, we suggest feature direction for research and potential therapeutic implications. This study showed that p130Cas/BCAR1 can affect cardiovascular diseases in various mechanisms including actin stress fiber formation, attachment to focal adhesion kinase (FAK) and angiotensin II (Ang II), generation of reactive oxygen species (ROS), and growth factor signaling through amplifying receptor tyrosine kinase (RTKs).