Radioclinical Profile of Eosinophilic Lung: A Case Series

TL;DR

This case series describes 17 patients with eosinophilic lung disease, focusing on their clinical and radiological features and treatment outcomes.

Contribution

The study provides a detailed radioclinical profile and treatment outcomes of patients with eosinophilic lung disease.

Findings

Most patients had chronic eosinophilic pneumonia, with radiological features including ground-glass opacities.

Systemic corticosteroids were effective, but some patients required additional immunosuppressive therapy.

Relapses were observed in five patients after discontinuing corticosteroid therapy.

Abstract

In this study, we present findings from an analysis of 17 patients diagnosed with eosinophilic lung disease, with a majority (64.70%) being male. The average age of the patients was 54 ± 13.22 years. A history of uncontrolled asthma was noted in nine cases. The clinical picture was characterized by persistent dyspnea and cough. Blood hypereosinophilia was present in all cases, with a median of 1770 cells/ul. Two patients had a pulmonary eosinophilia greater than 25%. Radiological findings were consistent with diffuse bilateral ground-glass opacities or areas of consolidation in the majority of cases. The main etiologies identified were chronic eosinophilic pneumonia (12 cases), followed by eosinophilic granulomatosis with polyangiitis (3 cases), idiopathic hypereosinophilic syndrome (1 case) and drug-induced hypereosinophilia (1 case). All patients were treated with systemic corticosteroids, with the addition of immunosuppressive therapy necessary in three cases. Notably, five relapses were recorded after corticosteroid therapy was stopped.

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