A Case Report on Breast Cancer Following Mantle Radiation for Hodgkin Lymphoma: Screening and Management

TL;DR

This case report highlights the risk of breast cancer in Hodgkin lymphoma survivors who had mantle radiation and discusses the need for better screening guidelines.

Contribution

The paper presents a case emphasizing the need for personalized screening strategies for breast cancer in Hodgkin lymphoma survivors.

Findings

Hodgkin lymphoma survivors who received mantle radiation are at increased risk of secondary cancers like breast cancer.

There is no consensus on optimal breast cancer screening frequency or modality for this high-risk population.

Personalized medicine is emphasized for managing cancer risk in Hodgkin lymphoma survivors.

Abstract

Hodgkin lymphoma survivors who received mantle radiation are at risk of developing secondary malignant neoplasms. There is no established recommended screening guideline for this population. We discuss the case of a patient with a history of Hodgkin lymphoma status post-mantle field radiation, thyroid cancer status post-thyroidectomy, and now breast cancer following mantle radiation. The risk of adverse effects from mantle field radiation is well documented and includes secondary cancers of the thyroid, breast, lung, and cardiovascular disease. Advances in technology have led to an international paradigm shift in the management of Hodgkin lymphoma to reduce the diameter and dose of radiation based on the patient’s anatomy. However, there is no consensus regarding the optimal frequency or modality of breast cancer screening in patients with Hodgkin lymphoma status post-mantle radiation who are now in remission. We discuss screening methods for this population, which has a high risk of developing breast cancer, and emphasize the need for personalized medicine.

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