Aleutian disease: Risk factors and ImmunAD strategy for genetic improvement of tolerance in American mink (Neogale vison)
Seyed Milad Vahedi, Siavash Salek Ardestani, Mohammad Hossein Banabazi, K. Fraser Clark
TL;DR
This study identifies risk factors for Aleutian disease in mink and proposes a new strategy to genetically improve tolerance to the disease.
Contribution
A novel ImmunAD strategy is introduced for genetic improvement of disease tolerance in American mink.
Findings
Age over 1 year, male sex, and year of sampling are significant risk factors for Aleutian disease.
ImmunAD has moderate-to-high heritability, with higher values in CIEP-positive animals.
High-coordinated immune responders show better breeding values for pelt quality and harvest length.
Abstract
Aleutian disease (AD) is a devastating infectious disease in American mink (Neogale vison) industry caused by Aleutian mink disease virus (AMDV). Two crucial steps toward controlling infectious diseases in farm animals are: (i) assessment of the infection risk factors to minimize the likelihood of infection and (ii) selection of animals with superior immune responses against pathogens to build tolerant farms. This study aimed to investigate AD risk factors and evaluate a novel “ImmunAD” approach for genetic improvement of AD tolerance. Phenotypic records and pedigree information of 1,366 and 24,633 animals were included in this study. The risk of animal’s age, sex, color type, and year of sampling on AMDV infection was assessed using a logistic regression model and counter immune-electrophoresis (CIEP) test results. ImmunAD phenotype was calculated based on AMDVG enzyme-linked…
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Taxonomy
TopicsHerpesvirus Infections and Treatments · Animal Disease Management and Epidemiology · Animal Virus Infections Studies