# Draft genome of a human-derived pks+ E. coli that caused spontaneous disseminated infection in a mouse

**Authors:** Allison M. Weis, O’Connor J. Matthews, Matthew A. Mulvey, June L. Round

PMC · DOI: 10.1128/mra.00387-24 · 2024-06-04

## TL;DR

This paper reports the genome of a human E. coli strain that caused infection in mice when transplanted.

## Contribution

The study provides a new genomic resource of an E. coli strain that spontaneously caused systemic infection in mice.

## Key findings

- A human-derived E. coli strain was found to disseminate from the gut to the kidneys in mice.
- The strain was isolated from a healthy human microbiota sample and is pks+.

## Abstract

We present the draft genome of a novel human-derived Escherichia coli strain isolated from a healthy control human microbiota that, when put into a mouse, spontaneously disseminated from the gut to the kidneys.

## Linked entities

- **Species:** Escherichia coli (taxon 562), Mus musculus (taxon 10090)

## Full-text entities

- **Diseases:** infection (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606], Escherichia coli (E. coli, species) [taxon 562], Mus musculus (house mouse, species) [taxon 10090]

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Source: https://tomesphere.com/paper/PMC11256781