# Exercise in Clinical Reasoning: Getting a Foothold on Lower Extremity Weakness

**Authors:** David Lester, Manisha Kotay, Qihua Fan, Gustave Weiland

PMC · DOI: 10.1007/s11606-024-08624-x · Journal of General Internal Medicine · 2024-03-21

## Full-text entities

- **Genes:** CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) [NCBI Gene 3156] {aka LDLCQ3, LGMDR28, MYPLG}, BTG3 (BTG anti-proliferation factor 3) [NCBI Gene 10950] {aka ANA, ANA/BTG3, APRO4, TOB5, TOB55, TOFA}, ACHE (acetylcholinesterase (Yt blood group)) [NCBI Gene 43] {aka ACEE, ARACHE, N-ACHE, YT}, MPO (myeloperoxidase) [NCBI Gene 4353], PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}
- **Diseases:** lymphomas (MESH:D008223), Cushing syndrome (MESH:D003480), motor weakness (MESH:D018908), smoking (MESH:D015208), hyperreflexia (MESH:D012021), multiple sclerosis (MESH:D009103), heliotrope rash (MESH:D005076), Proteinuria (MESH:D011507), Myopathy (MESH:D009135), peripheral vascular disease (MESH:D016491), adrenal insufficiency (MESH:D000309), Gottron papules (MESH:C538187), hypomagnesemia (OMIM:613882), interstitial lung disease (MESH:D017563), diabetic polyneuropathy (MESH:D003929), myoglobinuria (MESH:D009212), pyuria (MESH:D011776), tremor (MESH:D014202), incontinence (MESH:D014549), small-vessel vasculitis (MESH:C565222), cerebral (MESH:D002547), cord compression (MESH:D013117), hypokalemia (MESH:D007008), stiffness (MESH:C566112), Pitting edema (MESH:D004487), vitamin deficiencies (MESH:D014802), Oliguria (MESH:D009846), fatiguability (MESH:D005221), Lambert Eaton syndrome (MESH:D015624), GN (MESH:D005921), systemic lupus erythematosus (MESH:D008180), cramping (MESH:D009120), neurological and muscular (MESH:D009461), AAV (MESH:D056648), acute kidney injury (MESH:D058186), drug-induced vasculitis (MESH:D000081015), RPGN (MESH:C538458), Vasculitis (MESH:D014657), GBM (MESH:D005910), Dermatomyositis (MESH:D003882), hepatitis B (MESH:D006509), rigidity (MESH:D009127), LMN (MESH:D016472), fever (MESH:D005334), endocrine disorders (MESH:D004700), HIV (MESH:D015658), muscle tone (MESH:D009122), rhabdomyolysis (MESH:D012206), amyotrophic lateral sclerosis (MESH:D000690), demyelinating polyradiculoneuropathy (MESH:D020277), leukemias (MESH:D007938), diabetes (MESH:D003920), myalgias (MESH:D063806), neutrophilia (MESH:C563010), inflammatory syndrome (MESH:D018746), lower extremity weakness (MESH:D020335), sensory loss (MESH:C580162), fasciculations (MESH:D005207), hematuria (MESH:D006417), lumbar degenerative disease (MESH:D019636)
- **Chemicals:** Paraffin (MESH:D010232), allopurinol (MESH:D000493), atorvastatin (MESH:D000069059), Hydralazine (MESH:D006830), fluroquinolone (-), Rituximab (MESH:D000069283), H&E (MESH:D006371), penicillin (MESH:D010406), Propylthiouracil (MESH:D011441), prednisone (MESH:D011241), glucose (MESH:D005947), cephalosporins (MESH:D002511), alcohol (MESH:D000438), minocycline (MESH:D008911), urobilinogen (MESH:D014558), Magnesium (MESH:D008274), nitrites (MESH:D009573), sulfasalazine (MESH:D012460), metoprolol (MESH:D008790), Steroids (MESH:D013256), creatinine (MESH:D003404), potassium (MESH:D011188), D-penicillamine (MESH:D010396), acetylcholine (MESH:D000109)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11254865/full.md

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Source: https://tomesphere.com/paper/PMC11254865