Primary Sclerosing Cholangitis Associated With Ulcerative Colitis Coexisting With Cholangiocarcinoma: A Case Report

TL;DR

This case report describes a rare instance of primary sclerosing cholangitis linked to ulcerative colitis and cholangiocarcinoma in a young male patient.

Contribution

The novelty lies in documenting a rare coexistence of PSC, UC, and cholangiocarcinoma in a single patient.

Findings

A 33-year-old male presented with PSC, UC, and cholangiocarcinoma.

ERCP revealed beaded cholangiography due to multifocal bile duct strictures.

The case adds to the limited data on these rare overlapping pathologies.

Abstract

Primary sclerosing cholangitis (PSC) is a rare chronic inflammatory disease in which multifocal fibrosis of bile ducts causes eventually narrowing and even blocking, forming multifocal strictures alternated to dilatations. Here, we reported an extremely rare case of PSC associated with ulcerative colitis (UC) and coexisting with cholangiocarcinoma in a 33-year-old male presented with right upper quadrant pain and dark urine. Liver function tests were deranged, and ERCP found a beaded cholangiography appearance due to multifocal bile duct strictures alternating with normal and dilated segments of the common hepatic duct and the intrahepatic bile ducts. We aim to document this typical case of PSC associated with UC and coexisted with cholangiocarcinoma to add the existing data on these rare pathologies.

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