# Spontaneous Remission of Acute Lymphoblastic Leukemia Following Candida tropicalis Fungemia

## TL;DR

A young child with high-risk leukemia experienced a rare spontaneous remission after a fungal infection.

## Contribution

This case report highlights a rare instance of spontaneous remission following Candida tropicalis sepsis in a leukemia patient.

## Key findings

- A three-year-old with high-risk ALL experienced spontaneous remission after Candida tropicalis sepsis.
- The patient had received less than two months of treatment before the sepsis event.
- The case raises questions about the immunologic mechanisms behind spontaneous remission in leukemia.

## Abstract

Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a poorly understood phenomenon that has been sporadically reported in medical literature for over a century, and the molecular and immunologic mechanisms of remission pose interesting clinical questions. Furthermore, the often-transient nature of these remissions poses a challenge to physicians in formulating an approach to treatment. We report on a rare case of Candida tropicalis sepsis in a three-year-old female with high-risk ALL who received less than two months of treatment prior to sepsis and subsequent SR.