# Anatomic Locations and Metastatic Risk in Prostate Cancer in African Men: Insights From an African Cohort

## TL;DR

This study finds that prostate cancer in African men has higher metastatic risk depending on where the cancer is located in the prostate.

## Contribution

The study identifies specific prostate zones in African men with higher metastatic risk, offering insights for targeted management.

## Key findings

- Most prostate cancer lesions were in the peripheral and transitional zones.
- Lesions in the anterior fibromuscular stroma, central gland, and whole gland were linked to higher metastasis odds.
- Anterior fibromuscular stroma lesions were a marginally independent predictor of metastasis.

## Abstract

Background: There is significant variability in the pathogenetic characteristics of prostate cancer (PCa) across different anatomical zones. This study aims to understand the metastatic risk associated with these zonal predispositions among African men.

Methods: This hospital-based retrospective observational study included 120 biopsy-confirmed PCa patients examined between 2019 and 2023. Data on cancer history, sociodemographic, and clinical characteristics were collected from medical records. A logistic regression model was used to identify predictors of metastasis.

Results: The majority of PCa lesions were found in the left (60.0%) and right peripheral zones (55.8%), followed by the left (42.5%) and right transitional zones (41.7%). Lesions in the anterior fibromuscular stroma (crude odds ratio (cOR): 3.27, 95% confidence interval (CI): 1.13-9.47; p = 0.029), central gland (cOR: 5.38, 95% CI: 1.40-20.60; p = 0.014), and diffuse infiltration involving whole gland (cOR: 6.78, 95% CI: 1.17-30.07; p = 0.032) were associated with significantly increased odds of metastasis. Lesions in the anterior fibromuscular stroma were a marginally independent predictor of metastasis (adjusted odds ratio (aOR): 28.14, 95% CI: 0.96-822.46; p = 0.053).

Conclusions: This study underscores the variability in metastatic risk of PCa lesions across different anatomical zones in African men. Lesions in the anterior fibromuscular stroma, central gland, and diffuse infiltration involving the whole gland have higher odds of metastasis. These findings highlight the need for targeted diagnostic and therapeutic strategies based on lesion localization to improve PCa management in this population.