# Beyond the division of multiple sclerosis into different subgroups: The Concept of Connectomopathy

## TL;DR

The paper introduces the concept of connectomopathy to explain the unique progression of multiple sclerosis in each patient.

## Contribution

It proposes MS as a connectomopathy, where individual brain connectivity differences influence disease progression and treatment.

## Key findings

- MS is suggested to be a connectomopathy, where brain connectivity damage drives disease progression.
- Individual variations in the connectome challenge traditional MS classification into subgroups.
- The concept supports the need for personalized treatment approaches in MS patients.

## Abstract

Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients.