Oral Acantholytic Squamous Cell Carcinoma: A Rare Case of Mandibular Alveolar Ulceration

TL;DR

This case report describes a rare instance of acantholytic squamous cell carcinoma in the oral cavity of a 50-year-old man, successfully treated with surgery.

Contribution

The novelty lies in presenting a rare oral manifestation of acantholytic squamous cell carcinoma with detailed histopathological findings and successful treatment.

Findings

Acantholytic squamous cell carcinoma was diagnosed in a mandibular alveolar ulcer via biopsy.

Histopathology revealed acantholytic cells with a pseudo-glandular appearance.

Surgical resection with a split-thickness graft resulted in a successful outcome with no post-surgery complications.

Abstract

Acantholytic squamous cell carcinoma (ASCC) is an atypical form of squamous cell carcinoma (SCC). Although it is well known that ASCC typically appears in sun-exposed regions of the face and neck, oral cavity cases are incredibly rare. In this case report, we present a rare case of a 50-year-old male who developed an ulcer on his right mandibular alveolus, diagnosed with ASCC post-biopsy. On histopathological analysis, acantholytic cells with a pseudo-glandular appearance were observed. Subsequently, the tumor was resected by modified radical neck dissection with a split-thickness graft. The patient responded well to surgery and had no complications post-surgery.

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