# An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

## TL;DR

This study explores the role of GAB2 in various cancers, showing its abnormal expression and potential as a tumor marker.

## Contribution

The study provides a multidimensional analysis of GAB2's role in pan-cancer, including its phosphorylation, prognosis, and immune infiltration associations.

## Key findings

- GAB2 is abnormally expressed in various tumors and is linked to patient prognosis.
- Phosphorylated GAB2 shows expression differences between tumor and normal tissues.
- GAB2 interacts with Docetaxel and is associated with immune cell infiltration in tumors.

## Abstract

To explore the role of GAB2 in pan-cancer based on bioinformatics analysis.

Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer. We used Kaplan–Meier Plotter to analyze the relationship between GAB2 and OS and RFS in pan-cancer. We utilized the CPTAC database to examine the expression of phosphorylated GAB2 in pan-cancer. We investigated the effects of mutation features on the occurrence and development of human cancers by cBioPortal and COSMIC. Using the database, we conducted an analysis of molecular compounds that have the potential to interact with GAB2 through molecular docking. Moreover, we use the TIMER to explore the relationship between GAB2 and immune cell infiltration, and draw relevant heatmaps by R language.

GAB2 was abnormally expressed in various tumors and was associated with prognosis. There were differences in the expression of GAB2 phosphorylation in tumor tissues and corresponding normal tissues among different types of tumors. GAB2 interacts with Docetaxel and was associated with immune cell infiltration in various tumors.

GAB2 participates in regulating immune infiltration and affects the prognosis of patients. GAB2 may serve as a potential tumor marker.