# URJC-1: Stable and Efficient Catalyst for O-Arylation Cross-Coupling

## TL;DR

This paper introduces URJC-1, a stable and efficient catalyst for O-arylation cross-coupling reactions, showing high activity and reusability.

## Contribution

The novelty lies in the catalytic duality of URJC-1, combining Lewis acid and base centers in a single MOF structure for enhanced cross-coupling performance.

## Key findings

- URJC-1 achieved complete conversion of 4-nitrobenzaldehyde with only 3% mol copper concentration in one hour.
- The catalyst maintained its crystalline structure after five reaction cycles, showing high stability.
- Activating substituents and cyclic alcohols enhanced reaction activity with URJC-1.

## Abstract

The design of metal–organic frameworks (MOFs) allows the definition of properties for their final application in small-scale heterogeneous catalysis. Incorporating various catalytic centers within a single structure can produce a synergistic effect, which is particularly intriguing for cross-coupling reactions. The URJC-1 material exhibits catalytic duality: the metal centers act as Lewis acid centers, while the nitrogen atoms of the organic ligand must behave as basic centers. The impact of reaction temperature, catalyst concentration, and basic agent concentration was evaluated. Several copper-based catalysts, including homogeneous and heterogeneous MOF catalysts with and without the presence of nitrogen atoms in the organic ligand, were assessed for their catalytic effect under optimal conditions. Among the catalysts tested, URJC-1 exhibited the highest catalytic activity, achieving complete conversion of 4-nitrobenzaldehyde with only 3% mol copper concentration in one hour. Furthermore, URJC-1 maintained its crystalline structure even after five reaction cycles, demonstrating remarkable stability in the reaction medium. The study also examined the impact of various substituents of the substrate alcohol on the reaction using URJC-1. The results showed that the reaction had high activity when activating substituents were present and for most cyclic alcohols rather than linear ones.