# α-Carbonyl Rh-Carbenoid Initiated Cascade Assembly of Diazobarbiturates with Alkylidene Pyrazolones for Synthesis of Spirofuropyrimidines

## TL;DR

A rhodium-catalyzed reaction efficiently produces spirofuropyrimidines from diazobarbiturates and alkylidene pyrazolones.

## Contribution

A new cascade assembly method for synthesizing spirofuropyrimidines using Rh2(esp)2 and BINAP catalysts.

## Key findings

- The reaction achieved 38–96% yields of spirofuropyrimidines under optimized conditions.
- X-ray diffraction confirmed the chemical structure of the synthesized compounds.

## Abstract

Catalyzed by Rh2(esp)2 (10 mol%) and (±)-BINAP (20 mol%) in DCE at 80 °C, the cascade assembly between diazobarbiturates and alkylidene pyrazolones proceeded readily and produced spiro-furopyrimidines in 38–96% chemical yields. The chemical structure of the prepared spirofuro-pyrimidines was firmly confirmed by X-ray diffraction analysis.